Secretin and GIP

It was the first chemical messenger discovered by Bayliss and Starling in the year 1902. The historical significance is that the term hormone for chemical messengers has been coined by them after the discovery of secretin. It is secreted from the S cells of intestinal glands in the mucosa of the upper part of small intestine. The structure is very close to glucagon, VIP and GIP. Its half life in the circulation is 5 minutes.
Secretion of secretin is stimulated by the acid chyme entering the duodenum. The alkaline secretion produced by secretin, helps to neutralize the acidity.
Products of protein digestion in the upper part of small intestine stimulate secretin release. Actions of secretin:

  • Stimulates HCO3- secretion from the duct cells of pancreas and biliary duct
  • Causes watery alkaline pancreatic secretion
  • Augments the action of CCK on pancreatic acinar cells
  • Decreases gastric acid secretion
  • Causes contraction of pyloric sphincter.

GIP (gastric inhibitory peptide) is produced from K cells in the mucosa of duodenum and jejunum. Secretion of GIP is caused by the presence of glucose and fat in the duodenum.
Actions of GIP:
  • In large doses it causes inhibition of gastric secretion and motility
  • In smaller doses it does not show this action
  • Stimulates insulin secretion and forms one
    of the important β cell stimulating GI

Source: Textbook of Physiology, 3E (Chandramouli) (2010)